Esther González-Almela on Muck Rack

Esther González-Almela

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Articles

Herpes simplex virus type 1 reshapes host chromatin architecture via transcription machinery hijacking - Nature Communications

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By Francois Le Dily, Manuel Merino, Davide Carnevali, Luciano Di Croce, Esther González-Almela, Pol Cusco
| Nature
Abstract Herpes simplex virus type 1 (HSV-1) remodels the host chromatin structure and induces a host-to-virus transcriptional switch during lytic infection. We combine super-resolution imaging and chromosome-capture technologies to identify the mechanism of remodeling. We show that the host chromatin undergoes massive condensation caused by the hijacking of RNA polymerase II (RNAP II) and topoisomerase I (TOP1).
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