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Articles by Ethan Lippmann
Embryonic macrophages support endocrine commitment during human pancreatic differentiation
Human pancreatic development is a complex process orchestrated by a network of varying cell types that constitute the pancreatic niche.
Lippmann wins prestigious Chan Zuckerberg Initiative award to back research in the fight against Alzheimer’s
Ethan Lippmann, associate professor of chemical and biomolecular engineering and biomedical engineering, has won a Collaborative Pairs Pilot Project Award from the Chan Zuckerberg Initiative (CZI) to create a more effective way for the immune system to fight against neurodegenerative diseases like Alzheimer’s. The pilot project seeks to generate an immune response – or defense system – selectively around amyloid beta plaques, which are a key feature of Alzheimer’s disease.
A $3M NSF grant to advance biomanufacturing could help establish an innovative method to deliver medicines to cells Original
A team of Vanderbilt engineers, biologists and education specialists have received a $3 million grant from the National Science Foundation to advance large-scale biomanufacturing of cell-derived nanoparticles that can deliver precisely targeted drugs to the site of a disease.
Detection, visualization and quantification of protein complexes in human Alzheimer’s disease brains using proximity ligation assay - Scientific Reports
Abstract Examination of healthy and diseased human brain is essential to translational neuroscience. Protein–protein interactions play a pivotal role in physiological and pathological processes, but their detection is difficult, especially in aged and fixed human brain tissue. We used the in-situ proximity ligation assay (PLA) to broaden the range of molecular interactions assessable in-situ in the human neuropathology.
CRISPRi screens in human iPSC-derived astrocytes elucidate regulators of distinct inflammatory reactive states - Nature Neuroscience
Authors and Affiliations Institute for Neurodegenerative Diseases, University of California, San Francisco, San Francisco, CA, USA Kun Leng, Indigo V. L.
Despite limitations of pandemic, research continues in Basic Sciences, Engineering
Feb. 24, 2021, 8:00 AM By Jenna Somers Vanderbilt researchers are prolific and resolute in their pursuit of transformative research and innovation. During the Research Ramp-up process, more than 3,000 Vanderbilt research personnel have returned to in-person research activities, while many others have continued remotely through perseverance and ingenuity. On campus and at home, they are making discoveries that advance knowledge and improve lives.
Trans-institutional collaboration receives $2 million BRAIN Initiative grant, developing brain organoids to map neurological development
by Marissa Shapiro Feb. 1, 2021, 12:00 PM Vivian Gama, assistant professor of cell and developmental biology, and Leon Bellan, associate professor of mechanical engineering and biomedical engineering, have won a $2.3 million, three-year grant from the National Institutes of Health Brain Research through Advancing Innovative Neurotechnologies Initiative.
EHRs could clarify drug safety in pregnant people
Testing drug safety in people who are pregnant remains a wicked problem, but in the transition toward big data and machine learning, target trials could afford a viable alternative to randomized, controlled trials. References 1. Schachter, A. D. & Kohane, I. S. Reprod. Toxicol. 31, 562–569 (2011). 2. van der Graaf, R. et al. Trials 19, 78 (2018). 3. Labrecque, J. A. & Swanson, S. A. Eur. J. Epidemiol. 32, 473–475 (2017). 4. Goldstein, J. A., Bastarache, L. A., Denny, J. C., Pulley, J. M. & Aronoff, D. M. Am. J. Reprod.
Breaking Barriers: $2.5 million grant from Facebook CEO boosts researcher’s investigation into neurodegenerative disease
Parkinson’s disease is illustrated in this 3D image showing accumulation of protein deposits, as represented by small red spheres, in brain cells. (Lars Neumann/istock) Vanderbilt researcher Ethan Lippmann, assistant professor of chemical and biomolecular engineering, learned in December that he’d won $2.5 million as part of a wider grant from the Chan Zuckerberg Initiative to fund his work on neurodegenerative diseases.
Using Stem-Cell Technology, Researchers Succeed in ‘Growing’ a Working Blood-Brain Barrier
Researchers co-led by 2016 BBRF Young Investigator Ethan Lippmann, Ph.D., report they have succeeded in “building” vascular tissue that functions like the brain’s crucial protective membrane, called the blood-brain barrier. The barrier acts like a selective sieve, keeping large molecules including bacteria out of the brain and spinal fluid, but allowing oxygen, glucose, and other vital substances to enter.
First step toward model brain: turning iPSCs into working blood-brain barrier
by Heidi Hall Feb. 21, 2019, 3:41 PM Vanderbilt University engineering researchers took a major step toward building a “brain in a dish:” They cultured induced pluripotent stem cells into a successful three-dimensional blood-brain barrier model. The future of drug testing and disease research lies in creating organoids, or models of human organs, to determine efficacy and potency of medications.
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