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Etmar Bulk on Muck Rack

Etmar Bulk

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Articles

Co‐staining of KCa3.1 Channels in NSCLC Cells with a Small‐Molecule Fluorescent Probe and Antibody‐Based Indirect Immunofluorescence

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By Kathrin Brömmel, Marius Rieke, Sarah Maskri, Etmar Bulk
| Wiley
Abstract The Ca2+ activated potassium channel 3.1 (KCa3.1) is involved in critical steps of the metastatic cascade, such as proliferation, migration, invasion and extravasation. Therefore, a fast and efficient protocol for imaging of KCa3.1 channels was envisaged. The novel fluorescently labeled small molecule imaging probes 1 and 2 were synthesized by connecting a dimethylpyrrole‐based BODIPY dye with a derivative of the KCa3.1 channel inhibitor senicapoc via linkers of different length.
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