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Ettel Bubis on Muck Rack

Ettel Bubis

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Thrombin is increased in diabetic retinal pathology in the STZ mice model, and its attenuation by a specific inhibitor, PARIN5, is associated with preserved function

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By Zehavit Goldberg, Valery Golderman, Ofira Zloto, Efrat Shavit-Stein, Joab Chapman, Ifat Sher, Ygal Rotenstreich, Ettel Bubis, Tal Shadi
| Nature Verified
Abstract Diabetic retinopathy (DR) is a leading cause of vision loss in working-age adults. Retinal neurodegeneration precedes vascular pathology, highlighting the need to identify early molecular biomarkers as a target for intervention. The thrombin receptor, protease-activated receptor-1 (PAR1), a G-protein-coupled receptor involved in coagulation and neuroinflammatory signaling, is expressed in the retina and has been implicated in retinal barrier dysfunction and angiogenesis in late DR.
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