Euenio Gutiérrez-Jiménez

Abstract Microvascular pulsatility in the brain is crucial for sustaining the delicate balance between the brain's metabolic demands and blood supply, as it affects nutrient exchange, waste removal and blood-brain barrier permeability. Abnormal pulsatility, associated with ageing or vascular risk factors, may impair the clearance of metabolic waste or contribute to conditions such as cerebral small vessel disease, ultimately leading to dementia and increasing the risk of stroke.