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Metformin Improves Insulin Sensitivity in Muscles’ Microvascular System
Article title: Metformin improves skeletal muscle microvascular insulin resistance in metabolic syndrome Authors: Linda A. Jahn, Lee Hartline, Zhenqi Liu, Eugene J. Barrett From the authors: “Here, we provide the first evidence for metformin improving muscle microvascular insulin sensitivity in insulin-resistant humans.
Metformin improves skeletal muscle microvascular insulin resistance in metabolic syndrome
Metabolic syndrome closely associates with metabolic insulin resistance and increases the cardiovascular disease (CVD) event risk (1). Clinical interventions to lessen the risk of adverse outcomes from metabolic syndrome consist of lifestyle modification and treating syndrome components (i.e., hypertension, obesity, dysglycemia, hypertriglyceridemia, and low HDL cholesterol) (2). Other than dysglycemia, metformin does not target specific metabolic syndrome components.
Cardiac Outcomes After Screening for Asymptomatic Coronary Artery Disease in Patients With Type 2 Diabetes
Abstract Context Coronary artery disease (CAD) is the major cause of mortality and morbidity in patients with type 2 diabetes. But the utility of screening patients with type 2 diabetes for asymptomatic CAD is controversial. Objective To assess whether routine screening for CAD identifies patients with type 2 diabetes as being at high cardiac risk and whether it affects their cardiac outcomes.
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