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Articles by Eugene W. Gerner
Preclinical evaluation of the efficacy of α-Difluoromethylornithine and Sulindac against SARS-CoV-2 infection
Abstract Despite numerous research efforts and several effective vaccines and therapies developed against COronaVIrus Disease 2019 (COVID-19), drug repurposing remains an attractive alternative to identify new treatments for SARS-CoV-2 virus variants and other viral infections that may emerge in the future. Cellular polyamines support viral propagation and tumor growth.
Cancer pharmacoprevention: Targeting polyamine metabolism to manage risk factors for colon cancer
Cancer pharmacoprevention: Targeting polyamine metabolism to manage risk factors for colon cancer Eugene W. Gerner‡,§1, Elizabeth Bruckheimer‡ and Alfred Cohen‡ From ‡Cancer Prevention Pharmaceuticals, Tucson, Arizona 85718 and the §Department of Cell and Molecular Medicine, University of Arizona, Tucson, Arizona 85711 ↵1 To whom correspondence should be addressed: Professor Emeritus (retired), Cancer Prevention Pharmaceuticals, 1760 E. River Rd., Tucson, AZ 85716.
Cancer pharmacoprevention: Targeting polyamine metabolism to manage risk factors for colon cancer
Cancer pharmacoprevention: Targeting polyamine metabolism to manage risk factors for colon cancer Eugene W. Gerner‡,§1, Elizabeth Bruckheimer‡ and Alfred Cohen‡ From ‡Cancer Prevention Pharmaceuticals, Tucson, Arizona 85718 and the §Department of Cell and Molecular Medicine, University of Arizona, Tucson, Arizona 85711 ↵1 To whom correspondence should be addressed: Professor Emeritus (retired), Cancer Prevention Pharmaceuticals, 1760 E. River Rd., Tucson, AZ 85716.
Cancer pharmacoprevention: Targeting polyamine metabolism to manage risk factors for colon cancer
Cancer is a set of diseases characterized by uncontrolled cell growth. In certain cancers of the gastrointestinal tract, the adenomatous polyposis coli (APC) tumor suppressor gene is altered in either germline or somatic cells and causes formation of risk factors, such as benign colonic or intestinal neoplasia, which can progress to invasive cancer.
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