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Eui Min Jeong

As seen in: PLOS, BioRxiv
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Articles

How cells tame noise while maintaining ultrasensitive transcriptional responses

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By Eui Min Jeong, Jae Kyoung Kim, Chang Yoon Chung
| PLOS
Loading metrics Open Access Peer-reviewed Research Article ? This is an uncorrected proof. Citation: Jeong EM, Chung CY, Kim JK (2025) How cells tame noise while maintaining ultrasensitive transcriptional responses. PLoS Comput Biol 21(12): e1013217. https://doi.org/10.1371/journal.pcbi.1013217 Editor: Christopher E. Miles, University of Utah, UNITED STATES OF AMERICA Received: June 24, 2025; Accepted: December 3, 2025; Published: December 11, 2025 Copyright: © 2025 Jeong et al.
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A robust ultrasensitive transcriptional switch in noisy cellular environments

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By Eui Min Jeong, Jae Kyoung Kim
| BioRxiv
Abstract Ultrasensitive transcriptional switches enable sharp transitions between on and off states of transcription and are essential for cells to respond to environmental cues precisely. However, conventional switches, relying on direct repressor-DNA binding, are extremely sensitive to noise. Here, we discovered an alternative design combining three indirect transcriptional repression mechanisms, sequestration, blocking, and displacement, to generate a noise- resilient ultrasensitive switch.
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Robust Ultrasensitive Transcriptional Switch in Noisy Cellular Environments

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By Eui Min Jeong, Jae Kyoung Kim
| BioRxiv
Abstract Ultrasensitive transcriptional switches enable cells to make sharp transitions between on and off states of transcription, essential for cells to respond to environmental cues with high fidelity. However, conventional switches that rely on direct repressor-DNA binding are extremely sensitive to noise, leading to unintended changes in gene expression. This raises doubts about the effectiveness of these switches in noisy cellular environments.
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