Eva González-Barca
As seen in:
Wiley Online Library,
MDPI,
EClinicalMedicine,
The Lancet,
EMJ- European Medical Journal
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Ibrutinib followed by ofatumumab consolidation in previously untreated patients with chronic lymphocytic leukemia (CLL): GELLC-7 trial from the Spanish group of CLL (GELLC)
Research in context Several studies have analysed the combination of inhibitors of BTK (BTKi) with anti-CD20 monoclonal antibodies (mAbs) in patients with chronic lymphocytic leukemia (CLL), both in the frontline and relapsed or refractory settings.
Polatuzumab vedotin plus rituximab and lenalidomide in patients with relapsed or refractory diffuse large B-cell lymphoma: a cohort of a multicentre, single-arm, phase 1b/2 study
Summary Diffuse large B-cell lymphoma comprises nearly 30% of non-Hodgkin lymphoma cases and patients with relapsed or refractory diffuse large B-cell lymphoma who are ineligible for stem-cell transplantation have few treatment options and poor prognoses.
What to Do When Chimeric Antigen Receptor T Cells Are Not the Most Appropriate Option in Second-Line Diffuse Large B Cell Lymphoma: Current Treatment Options for Transplant-Ineligible Patients
The patient was not eligible for ASCT due to age and comorbidities, and González-Barca explained that if CAR-T therapy had been available to the patient at this time, they would have been ineligible because they progressed >12 months after 1L therapy. When this patient relapsed in 2020, available treatment options included R-GemOx and R-Benda.
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