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Articles by Evan Appleton
Derivation of elephant induced pluripotent stem cells
Abstract Biodiversity loss in the present era requires new tools for studying nonmodel organisms. Elephants are both an endangered species and excellent models for studying complex phenotypes including size, social behavior and longevity. Here we report the first derivation of elephant (Elephas maximus) induced pluripotent stem (emiPS) cells.
Iterative transcription factor screening enables rapid generation of microglia-like cells from human iPSC - Nature Communications
Abstract Differentiation of induced pluripotent stem cells (iPSCs) into specialized cell types is essential for uncovering cell-type specific molecular mechanisms and interrogating cellular function. Transcription factor screens have enabled efficient production of a few cell types; however, engineering cell types that require complex transcription factor combinations remains challenging.
DERIVATION OF ELEPHANT INDUCED PLURIPOTENT STEM CELLS
Abstract The crisis of biodiversity loss in the anthropogenic era requires new tools for studying non-model organisms. Elephants, for example, are both an endangered species and excellent models studying complex phenotypes like size, social behavior, and longevity, but they remain severely understudied.
Targeted intracellular delivery of Cas13 and Cas9 nucleases using bacterial toxin-based platforms
Highlights • Development of modular delivery platforms based on diphtheria toxin and BoNT/X • Targeted intracellular delivery of Cas13a, CasRx, Cas9, and Cre proteins is validated • Delivery of Cas13 reduces mRNAs of targeted genes and SARS-CoV-2 reporters in cells • Delivery of Cas9 generates on-site mutations in cell lines and iPSC-derived neurons Summary Targeted delivery of therapeutic proteins toward specific cells and across cell membranes remains major challenges.
A computer-guided design tool to increase the efficiency of cellular conversions
Abstract Human cell conversion technology has become an important tool for devising new cell transplantation therapies, generating disease models and testing gene therapies. However, while transcription factor over-expression-based methods have shown great promise in generating cell types in vitro, they often endure low conversion efficiency.
Algorithms for the selection of fluorescent reporters
Abstract Molecular biologists rely on the use of fluorescent probes to take measurements of their model systems. These fluorophores fall into various classes (e.g. fluorescent dyes, fluorescent proteins, etc.), but they all share some general properties (such as excitation and emission spectra, brightness) and require similar equipment for data acquisition.
Regulating gene drives
Genes in sexually reproducing organisms normally have, on average, a 50% chance of being inherited, but some genes have a higher chance of being inherited. These genes can increase in relative frequency in a population even if they reduce the odds that each organism will reproduce. Aided by technological advances, scientists are investigating how populations might be altered by adding, disrupting, or editing genes or suppressed by propagating traits that reduce reproductive capacity (1, 2).
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