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Evelyn Sandra Vincow on Muck Rack

Evelyn Sandra Vincow

As seen in: BioRxiv
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Articles

Glucocerebrosidase deficiency leads to neuropathology via cellular immune activation

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By Ruth Thomas, Gautam Pareek, Evelyn Sandra Vincow, Gillian Milstein
| BioRxiv
Abstract Mutations in GBA (glucosylceramidase beta), which encodes the lysosomal enzyme glucocerebrosidase (GCase), are the strongest genetic risk factor for the neurodegenerative disorders Parkinson's disease (PD) and Lewy body dementia. Recent work has suggested that neuroinflammation may be an important factor in the risk conferred by GBA mutations. We therefore systematically tested the contributions of immune-related genes to neuropathology in a Drosophila model of GCase deficiency.
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