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Even Walseng

As seen in: Nature, The Journal of Biological Chemistry
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Articles by Even Walseng

Harnessing a catalytic lysine residue for the one-step preparation of homogeneous antibody-drug conjugates

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By Alex R. Nanna, Xiuling Li, Even Walseng, Lee Pedzisa
| Nature Verified
All variable domain sequences were based on published or patented amino acid sequences. All DVDs were prepared using amino acid sequences previously described44. Anti-HER2 DVDs were prepared by linking the VH and VL of trastuzumab to the VH and VL of h38C2 via a short (ASTKGP; the N-terminal 6 amino acids of human CH1) or long (TVAAPSVFIFPP; the N-terminal 12 amino acids of human C?) spacer for anti-HER2-DVD1 and anti-HER2 DVD2, respectively.
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Chemically Programmed Bispecific Antibodies in Diabody Format

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By Even Walseng, Christopher Nelson, Junpeng Qi, Alex R. Nanna
| The Journal of Biological Chemistry Verified
Chemically programmed bispecific antibodies (biAbs) endow target cell-binding small molecules with the ability to recruit and activate effector cells of the immune system. Here we report a platform of chemically programmed biAbs aimed at redirecting cytotoxic T cells to eliminate cancer cells.
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Chemically programmed bispecific antibodies in diabody format

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By Christopher Nelson, Junpeng Qi, Even Walseng, Alex R. Nanna
| The Journal of Biological Chemistry Verified
Author contributions: C.R. conceived, designed, supervised, and analyzed experiments; E.W. conceived, designed, conducted, and analyzed biological syntheses, biochemical conjugations, and in vitro and in vivo experiments; T.R.B. Jr. conceived, designed, analyzed, and supervised chemical syntheses; C.G.N. conceived, designed, conducted, and analyzed chemical syntheses; J.Q. conducted and analyzed in vitro experiments; A.R.N. conducted and analyzed chemical syntheses and in vitro experiments;...
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