Skip To Main Content
Evmorfia V. Dalietou on Muck Rack

Evmorfia V. Dalietou

As seen in: Nature
Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work. Claim your profile

Get in touch with Evmorfia V.

Contact Evmorfia V., search articles and posts on X, monitor coverage, and track replies from one place.

Learn more about Muck Rack

Actions

Share this page

Is this you?

As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile

Articles

Structural determinants for FAT10 activation and transfer from UBA6 to E2 enzymes

|
By Cara Ellison, Michael Simmons, Emma Dodd, Paul Elliott, Carlos Riechmann, Evmorfia V. Dalietou
| Nature Verified
Abstract Attachment of the ubiquitin-like protein (UBL) FAT10 onto substrates targets them for proteasomal degradation. Like ubiquitin, FAT10 is activated by the E1 enzyme UBA6 then transferred to E2 enzymes, but mechanisms controlling ubiquitin versus FAT10 activation by UBA6 and FAT10 transfer onto E2s remain unclear. Using cryo-EM, we visualise all stages of FAT10 E1-E2 handover: adenylation, thiolation and transthiolation.
Open in Who Shared Issue with article?
See all 1 articles