Exarchos Kanelis on Muck Rack

Exarchos Kanelis

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TNF induces catabolism in human cartilaginous endplate cells in 3D agarose culture under dynamic compression - Scientific Reports

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By Katherine B. Crump, Maria Segarra-Queralt, Paola Bermudez-Lekerika, Liesbet Geris, Leonidas Alexopoulos, Jerome Noailly, Exarchos Kanelis, Andreu Pascuet-Fontanet, Ahmad Alminnawi
| Nature
Abstract Intervertebral disc (IVD) degeneration is the leading cause of low back pain in young adults, and the cartilaginous endplate (CEP) is likely to play a key role in early IVD degeneration. To elucidate the effects of pro-inflammatory cytokines on the mechanobiology of the CEP, human CEP cells were seeded into 2% agarose, dynamically compressed up to 7%, and stimulated with tumor necrosis factor (TNF).
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