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Deciphering opening mechanisms of 14‐3‐3 proteins
1 INTRODUCTION The 14-3-3 family of proteins was identified in 1966, after a systematic analysis of calf brain proteins (Moore et al., 1968; Moore & Perez, 1967). Its name reflected the fraction number during chromatographic separation and the position on gel electrophoresis.
Evolutionary and Structural Constraints Influencing Apolipoprotein A-I Amyloid Behavior
Abstract Apolipoprotein A-I (apoA-I) has a key function in the reverse cholesterol transport mediated by the high density lipoprotein (HDL) particles. However, aggregation of apoA-I single point mutants can lead to hereditary amyloid pathology.
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