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Exian Mou on Muck Rack

Exian Mou

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Articles

Beyond estrobolome 1.0: unraveling endocrine-microbiome axis as a driver and therapeutic target in hormone-driven cancers

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By Rui Guo, Yong Yi, Yutang Yao, Jia Xu, Exian Mou
| Nature Verified
Abstract The endocrine-microbiome axis extends the estrobolome concept, recognizing gut microbes as active endocrine partners. Bacteria modulate estrogen recycling via diverse enzymes and produce SERM-like metabolites, while host hormones shape microbial communities. This bidirectional crosstalk influences hormone-driven carcinogenesis through inflammation, genomic instability, and epigenetic changes. Therapeutic opportunities include precision probiotics and selective enzymatic inhibition.
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