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F. Christopher Peritore-Galve on Muck Rack

F. Christopher Peritore-Galve

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Articles

Mucosal vaccination clears Clostridioides difficile colonization - Nature

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By Audrey Thomas, F. Christopher Peritore-Galve, Alyssa G. Ehni, Jonathan Coggin, Eric Brady, Sandra M. Yoder, Rebecca A. Shrem, Ruben Rodriguez, Heather K. Kroh, Katherine N. Gibson-Corley, M. Kay Washington, Danyvid Olivares-Villagómez, C. Buddy Creech, Maribeth R. Nicholson, Benjamin W. Spiller, D. Borden Lacy, Bruno B. C. Lança
| Nature Verified
Abstract Clostridioides difficile infection (CDI) is the leading cause of healthcare- and antibiotic-associated infection and has a 30% recurrence rate1,2,3,4,5. Previous vaccine strategies against CDI failed to reduce pathogen burden, a prerequisite for preventing C. difficile transmission and recurrence6,7,8,9,10,11. These vaccines were administered parenterally, which induced a systemic immune response, rather than a mucosal response in the colon, the site of infection.
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