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F. Isil Yapici on Muck Rack

F. Isil Yapici

As seen in: Nature
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Articles

An atlas of ferroptosis-induced secretomes - Cell Death & Differentiation

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By F. Isil Yapici, Eric Seidel, Alina Dahlhaus, Christina Schmidt, Emre Güngör, Jan-Wilm Lackmann, Peter Kreuzaler, Almut Schulze, Maria Nenchova, Christina M. Bebber
| Nature Verified
Abstract Cells undergoing regulated necrosis systemically communicate with the immune system via the release of protein and non-protein secretomes. Ferroptosis is a recently described iron-dependent type of regulated necrosis driven by massive lipid peroxidation. While membrane rupture occurs during ferroptosis, a comprehensive appraisal of ferroptotic secretomes and their potential biological activity has been lacking.
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Ferroptosis spreads to neighboring cells via plasma membrane contacts - Nature Communications

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By Matthias Rübsam, Silvia von Karstedt, Carien M. Niessen, Bernhard F. Roeck, F. Isil Yapici
| Nature Verified
Abstract Ferroptosis is a lytic, iron-dependent form of regulated cell death characterized by excessive lipid peroxidation and associated with necrosis spread in diseased tissues through unknown mechanisms. Using a novel optogenetic system for light-driven ferroptosis induction via degradation of the anti-ferroptotic protein GPX4, we show that lipid peroxidation and ferroptotic death can spread to neighboring cells through their closely adjacent plasma membranes.
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