Fabeha Fazal on Muck Rack

Fabeha Fazal

As seen in: The Journal of Immunology
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Articles

Phosphodiesterase 10A Is a Key Mediator of Lung Inflammation

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By Chia George Hsu, Fabeha Fazal, Arshad Rahman, Bradford C. Berk
| The Journal of Immunology Verified
Chia George Hsu, Fabeha Fazal, Arshad Rahman, Bradford C. Berk and Chen Yan J Immunol June 15, 2021, 206 (12) 3010-3020; DOI: https://doi.org/10.4049/jimmunol.2001026 Key Points LPS induces PDE10A upregulation in macrophages in vitro and in lung tissues. PDE10A regulates MCP-1 production in macrophages. PDE10A inhibition reduces lung inflammation in mouse models of LPS exposure. Abstract Cyclic nucleotides cAMP and cGMP are important regulators of immune cell functions.
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Phosphodiesterase 10A Is a Key Mediator of Lung Inflammation

|
By Bradford C. Berk, Chia George Hsu, Fabeha Fazal, Arshad Rahman
| The Journal of Immunology Verified
Chia George Hsu, Fabeha Fazal, Arshad Rahman, Bradford C. Berk and Chen Yan J Immunol June 7, 2021, ji2001026; DOI: https://doi.org/10.4049/jimmunol.2001026 Key Points LPS induces PDE10A upregulation in macrophages in vitro and in lung tissues. PDE10A regulates MCP-1 production in macrophages. PDE10A inhibition reduces lung inflammation in mouse models of LPS exposure. Abstract Cyclic nucleotides cAMP and cGMP are important regulators of immune cell functions.
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