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Fabíola Barbieri Holetz on Muck Rack

Fabíola Barbieri Holetz

As seen in: Nature, PLOS ONE, MDPI, BioRxiv
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Articles

Euglena gracilis as a high-throughput screening platform for antibacterial activity, cytotoxicity and membrane permeability in a one-step and cost-effective assay

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By Leticia Radin Pereira, Letícia N. Pereira, Susanne H. Kirsch, Marc Stadler, Fabíola Barbieri Holetz, Rolf Müller, Susanne Kramer, Lea-Sophie Löffler, Birthe Sandargo
| Nature Verified
Abstract There is an urgent need for the development of new antibacterial drugs, caused by the increasing number of resistances. The first step for the development of new antibacterial compounds is usually a high-throughput screen of naturally occurring or synthetic compounds. Here, we propose to screen compound libraries on the Euglenoid Euglena gracilis.
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Trypanosomes lack a canonical EJC but possess an UPF1 dependent NMD-like pathway

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By Bernardo Papini Gabiatti, Eden Freire, Johanna Odenwald, Fabíola Barbieri Holetz
| PLOS ONE
Loading metrics Open Access Peer-reviewed Research Article Citation: Gabiatti BP, Freire ER, Odenwald J, de Freitas Nascimento J, Holetz F, Carrington M, et al. (2025) Trypanosomes lack a canonical EJC but possess an UPF1 dependent NMD-like pathway. PLoS ONE 20(3): e0315659.
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Intron-loss in Kinetoplastea correlates with a non-functional EJC and loss of NMD factors

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By Bernardo Papini Gabiatti, Eden Freire, Johanna Odenwald, Fabíola Barbieri Holetz
| BioRxiv
Abstract In metazoans, mRNA quality is tightly monitored from transcription to translation. A key role lies with the exon junction complex (EJC) that is placed upstream of the exon-exon junction after splicing. The EJC inner core is composed of Magoh, Y14, eIF4AIII and BTZ and the outer core of proteins involved in mRNA splicing (CWC22), export (Yra1), translation (PYM) and non-sense mediated decay (NMD, UPF1/2/3).
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