Fabrizia Campana

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1. Introduction Diagnosing lymphoma relies on evaluating samples for morphological examination, immunophenotypic analysis, genetic profiling, and molecular characterization. However, obtaining these samples can be challenging, depending on their location [1]. In cases where the lymph node or pathological extra-nodal tissue is superficially located, an excisional biopsy is recommended. However, for deep-seated lesions, a surgical biopsy may be overly invasive and requires general anesthesia.