Faezzah Baharom on Muck Rack

Faezzah Baharom

As seen in: Nature, PLOS, The Journal of Immunology
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Articles

A genetically engineered therapeutic lectin inhibits human influenza A virus infection and sustains robust virus-specific CD8 T cell expansion

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By Meng Yu, Ang Lin, Faezzah Baharom, PLOS Pathogens
| PLOS
Loading metrics Open Access Peer-reviewed Research Article Citation: Yu M, Lin A, Baharom F, Li S, Legendre M, Covés-Datson E, et al. (2025) A genetically engineered therapeutic lectin inhibits human influenza A virus infection and sustains robust virus-specific CD8 T cell expansion. PLoS Pathog 21(5): e1013112.
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Vax-Innate: improving therapeutic cancer vaccines by modulating T cells and the tumour microenvironment - Nature Reviews Immunology

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By Faezzah Baharom, Dalton Hermans, Lélia Delamarre
| Nature Verified
Abstract T cells have a critical role in mediating antitumour immunity. The success of immune checkpoint inhibitors (ICIs) for cancer treatment highlights how enhancing endogenous T cell responses can mediate tumour regression. However, mortality remains high for many cancers, especially in the metastatic setting.
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A genetically engineered therapeutic lectin inhibits human influenza A virus infection and sustains robust virus-specific CD8 T cell expansion

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By Meng Yu, Ang Lin, Faezzah Baharom, Shuijie Li
| biorxiv.org
Abstract Native banana lectin (BanLec) is antiviral but highly mitogenic, which limits its therapeutic value. In contrast, the genetically engineered H84T BanLec (H84T) is not mitogenic but remains effective against influenza A virus (IAV) infection in mouse models. However, the potency and effect of H84T on human immune cells and IAV-specific immune responses is undetermined.
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