Fan-En Kong on Muck Rack

Fan-En Kong

As seen in: Science Magazine
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Targeting tumor lineage plasticity in hepatocellular carcinoma using an anti-CLDN6 antibody-drug conjugate

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By Fan-En Kong, Guang-Meng Li, Yun-Qiang Tang, Shao-Yan Xi
| Science Magazine
Targeting tumor lineage plasticity Lineage plasticity allows tumor cells to evolve during anticancer treatment, resulting in therapeutic resistance. Here, Kong et al. found that claudin6 was reactivated in hepatocellular carcinoma tumor tissue and shifted cell phenotype to the biliary lineage, which was refractory to treatment with the kinase inhibitor sorafenib.
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