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Fan-rong Wu

As seen in: Nature
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Articles

ASIC1a promotes liver fibrosis by inhibiting METTL3 SUMOylation Original

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By Zi-Hao Li, Ting-Ting Zhang, Kiramat Ali Shah, Yu-Yan Wang, Zi-Jun Liu, Hao-Yang Chen, Zhou Xu, Lynn Tay, Zi-Wen Zhang, Jun Liu, Fu-Rong Yang, Hui Hou, Wu-yi Sun, Hua Wang, Jia-Jia Wang, Yan Huang, Meng-xue Li, Yong-hu Song, Ruo-han Ren, Wan-jing Huang, Asena Musonye Harry, Shis-hun Qian, Jing-rong Zhang, Cheng-mu Hu, Xiang-peng Hu, Fan-rong Wu
| Nature Verified
Abstract Liver fibrosis represents a major global health burden, with its core pathological feature being the excessive deposition of extracellular matrix driven by activated hepatic stellate cells (HSCs). Acid-sensitive ion channel 1a (ASIC1a) has been shown to be associated with the progression of liver fibrosis, but the molecular mechanisms by which it regulates RNA m6A methylation remain unclear.
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