1 INTRODUCTION The incidence of peripheral arterial disease, which includes lower limb atherosclerotic occlusive disease (ASO), has increased in tandem with challenges that our societies confront from an ageing population.1, 2 Because it causes chronic ischaemia, ASO, which is defined by atherosclerotic plaque accumulation that results in arterial stenosis and occlusion, is extremely common and poses a major risk to limb viability.3 The pathophysiology of atherosclerosis, which underpins not...
