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Fangying Su

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Articles

B7-H3 promotes skin photodamage through ITGA2-NRF2-TFAM-mediated mitochondrial oxidative stress

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By Yuanyuan Jia, Qiange Zhang, Yuan Yi Zhu, Siji Chen, Jingyi Yang, Qiuyu Mao, Yiwen Zhang, Yuting Yang, Cuiping Liu, Xueguang Zhang, Dan Luo, Wei Min, Lei Cao, Fangying Su
| Nature Verified
Abstract Ultraviolet radiation (UVR) exposure drives skin photodamage, which constitutes the fundamental basis of both photoaging and photocarcinogenesis, by disrupting mitochondrial homeostasis and inducing reactive oxygen species (ROS) accumulation. Although B7-H3 (CD276) is recognized as an immune-checkpoint molecule involved in tumor metabolism, its role in UVR-induced cutaneous photodamage and the associated redox imbalance remains undefined.
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