Fanni Adél Meznerics

Abstract Malignant melanoma is responsible for most skin cancer–related deaths due to its unpredictable behavior. Serum biomarkers have been widely investigated to improve prognostic assessment, yet their clinical utility remains inconclusive. This systematic review and meta-analysis evaluated the prognostic significance of serum biomarkers in melanoma.

1 Introduction Prurigo nodularis (PN) is a chronic inflammatory skin disease that usually presents with pruritic nodules on the extensor surfaces of the extremities and trunk and is characterized by a vicious itch-scratch cycle [1, 2]. The estimated prevalence is 72 per 100.000, but the actual number of patients may be higher [3]. Patients have a significantly reduced quality of life, with subsequent depression, anxiety, sleep disturbances, and even suicidal tendencies [4-7].

Corresponding Author Norbert Kiss Department of Dermatology, Venereology and Dermato-oncology, Faculty of Medicine, Semmelweis University, Budapest, Hungary Centre for Translational Medicine, Semmelweis University, Budapest, Hungary Correspondence Norbert Kiss, Department of Dermatology, Venereology and Dermatooncology, Faculty of Medicine, Semmelweis University, 41 Mária utca, Budapest 1085, Hungary. Email: kiss.norbert@semmelweis.hu Search for more papers by this author