Fantian Zeng

1 Introduction Patients receiving chemotherapeutics are often at high risk of acute kidney injury (AKI) due to the inevitable renal excretion of chemotherapy drugs.[1] The chemotherapeutic drug-induced AKI featuring rapid deterioration of renal functions may progress into advanced complications, including chronic kidney disease, renal failure, and death.[2] Generally, the pathogenesis of AKI involves diverse modalities of regulated cell death, including ferroptosis, necroptosis, and...

Abstract Understanding the molecular machinery regulating ferroptosis and leveraging this accumulating knowledge could facilitate disease prevention, diagnosis, treatment, and prognosis. The emerging approaches endowing in situ detection of the major regulators of ferroptosis at the cellular and tissue levels, and in living subjects, provide a multi-scale perspective to study ferroptosis.

2. Curcumin Scaffold as a Tool for Understanding AD Aβ plaques represent a classical pathology which is found in the AD brain. Aβ peptide usually undergoes conformation changes from monomer to oligomers and fibers that are rich in β-sheets [36]. Martin et al. analyzed the dynamics and energetics between curcumin and 24-peptide in Aβ fibrils using molecular dynamics simulations.