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Faqrul Hasan on Muck Rack

Faqrul Hasan

As seen in: MDPI
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Articles

Cancers | Free Full-Text | TIGIT Expression on Activated NK Cells Correlates with Greater Anti-Tumor Activity but Promotes Functional Decline upon Lung Cancer Exposure: Implications for Adoptive Cell Therapy and TIGIT-Targeted Therapies

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By Tayler J. Croom-Perez, Jeremiah L. Oyer, Faqrul Hasan, Thomas A. Dieffenthaller
| MDPI
Abstract : Simple Summary Therapies targeting TIGIT have garnered tremendous interest, but have so far failed to reach primary endpoints in PhIII trials in lung cancer settings. This study examined the function of TIGIT on NK cells and how NK cells may impact the success of TIGIT therapeutics. This study demonstrated that TIGIT expression is increased on activated NK cells, including those expanded with clinical protocols for cell therapy.
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