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The gold complex auranofin sensitizes platinum resistant epithelial ovarian cancer cells to cisplatin
Abstract Although there are numerous studies on drug development for ovarian cancer (OC), survival rates for this disease remain low due to platinum (Pt) resistance. Following several rounds of Pt-based chemotherapy, OC cells develop resistance by increasing DNA repair and antioxidant systems. This study aimed to design a treatment approach to combat recurrent stages of OC by repurposing the anti-rheumatic gold complex auranofin (AF).
Cancers | Free Full-Text | Pro-Oxidant Auranofin and Glutathione-Depleting Combination Unveils Synergistic Lethality in Glioblastoma Cells with Aberrant Epidermal Growth Factor Receptor Expression
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Auranofin Induces Lethality Driven by Reactive Oxygen Species in High-Grade Serous Ovarian Cancer Cells
2. Materials and Methods 2.1. Reagents and Cell Lines PEO1 cells are epithelial ovarian cancer cells isolated from a patient after their first relapse 22 months following treatment with cisplatin, 5-fluorouracil, and chlorambucil, while the patient was still sensitive to platinum-based chemotherapy. PEO4 cells were subsequently isolated from the same patient after the second relapse in which the patient was no longer sensitive to chemotherapy.
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