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Fatema Nakhuda on Muck Rack

Fatema Nakhuda

As seen in: BioRxiv

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Articles

Pannexin-2 deficiency disrupts visual pathways and leads to ocular defects in zebrafish

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By Riya Shanbhag, Fatema Nakhuda, Shiva Sabour, Heike Naumann
| BioRxiv
Abstract Pannexin-2 (Panx2) is a unique ion channel localized to ER-mitochondria contact sites. These dynamic and specialized microdomains are abundant in neurons and glia and essential for cellular signaling and metabolism. While synaptic interactions are well-studied, the role of intracellular contacts, such as those of ER-mitochondrial junctions, in neuronal function and neurodegeneration remains largely unexplored.
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Pannexin-2 deficient zebrafish develop ocular and visual motor behaviour defects

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By Fatema Nakhuda, Christiane Zoidl, Riya Shanbhag, Shiva Sabour
| BioRxiv
Abstract Pannexin-2 (Panx2), unlike the other pannexin channels Panx1 and Panx3, exhibits a unique intracellular distribution, localizing at ER-mitochondria contact sites. These specialized microdomains are crucial for important cellular functions, including calcium homeostasis, lipid transfer, inflammation, and apoptosis. Despite their presence in neurons and glial cells, the function of Panx2 at ER-mitochondria contact sites in neurotransmission remains unclear.
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