Fatlum Rruga on Muck Rack

Fatlum Rruga

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Improvement and extension of anti-EGFR targeting in breast cancer therapy by integration with the Avidin-Nucleic-Acid-Nano-Assemblies

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By Francesco Roncato, Fatlum Rruga, Elena Porcù, Elisabetta Casarin
| Nature
The ANANAS nanoparticles are essentially “soft” polyavidins. A single NP contains ~ 50 avidins and 1200 biotin-binding sites (BBS) and has ~6000 nm2 available for surface functionalization.11,12,13 They can be functionalized with stoichiometric control by simply mixing with biotinylated functional elements at desired biotin:BBS molar ratios and no purification is necessary if neither the BBS become saturated nor the surface area available is exceeded11,12,13.
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