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Faustus Tuschmann

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Articles

Decoding the regulatory programs governing glioblastoma plasticity

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By Manu Saraswat, Laura Rueda-Gensini, Elisa Heinzelmann, Tannia Gracia, Fani Memi, Grant de Jong, Jannes Straub, Dirk C Hoffmann, Erik Jung, Tim Kindinger, Louis Masclef, Bettina Weigel, Bryce Lim, Sophie Weil, Oliver Gould, Richard Mair, Wolfgang Wick, Frank Winkler, Omer Ali Bayraktar, Oliver Stegle, Moritz Mall, Cedar Schloo, Faustus Tuschmann, Katharina Mikulik, Martin Rohbeck
| Nature Verified
Abstract Glioblastoma is incurable and resistant to therapy despite genomic stability under treatment1,2,3,4,5,6,7,8, suggesting that non-genetic cellular plasticity is a central driver of progression. Whether such plasticity reflects stochastic state switching or is governed by predictable gene regulation has remained unclear9,10,11,12,13.
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