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Fayin Zhu on Muck Rack

Fayin Zhu

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Engineering a new-to-nature cascade for phosphate-dependent formate to formaldehyde conversion in vitro and in vivo - Nature Communications

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By Pascal Pfister, Hai He, Seung Hwan Lee, Witold Szymanski, Fayin Zhu, Charlotte Wallner, Jan Zarzycki, Giancarlo Franciò, Ramon Gonzalez
| Nature Verified
Abstract Formate can be envisioned at the core of a carbon-neutral bioeconomy, where it is produced from CO2 by (electro-)chemical means and converted into value-added products by enzymatic cascades or engineered microbes. A key step in expanding synthetic formate assimilation is its thermodynamically challenging reduction to formaldehyde. Here, we develop a two-enzyme route in which formate is activated to formyl phosphate and subsequently reduced to formaldehyde.
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