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Articles

AA amyloidosis in the four historical monogenic autoinflammatory diseases: Clinical burden and insights from a retrospective referral-centre study

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By Majdouline El Moussaoui, Léa Savey, Fédération Hospitalo
| Wiley Online Library Verified
Despite major advances in molecular diagnostics and the development of targeted biologic therapies, AA amyloidosis (AAA) remains one of the most severe complications of systemic autoinflammatory disorders (AIDs) [1, 2]. Although the incidence of AAA has declined markedly since the introduction of interleukin-1 (IL-1) inhibitors and earlier disease recognition, it continues to emerge in a clinically meaningful subset of patients, driving substantial morbidity and mortality [1-3].
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