Federico Fierli

Abstract Parkinson disease is a neurodegenerative disorder characterised by impairment of motor function, and is associated with a progressive accumulation of insoluble aggregates of misfolded alpha-synuclein. In the present study, we exploited the SH-SY5Y cell model overexpressing a pro-aggregation form of alpha-synuclein to investigate the efficacy of PIKfyve-mediated lysosomal biogenesis, through TFEB, as potential target for Parkinson therapy.

By Anu-Maija Sundström, Julia Wagemann, Julien Chimot, Federico Fierli and Mark Parrington The first major wildfire episodes of the 2023 boreal zone fire season are ongoing in Alberta, Canada and Siberia. In these areas fire danger is typically high during spring, after the snow melts and before the vegetation greens up. In early May, temperatures have been much higher than normal, especially in Alberta, with soil moisture lower than normal.

By Anu-Maija Sundström (FMI), Julia Wageman (MEEO), Federico Fierli Satellites are increasingly used to monitor air quality and transport of atmospheric pollution. The advantages of satellite data are that they provide data from regional to global scale, and they can help to fill the gaps between the ground-based measurement stations. Satellites also provide observations over areas where no other measurements are available.