Federico Paolini Paoletti

Abstract Accurate diagnosis of dementia with Lewy bodies (DLB) remains challenging, with misdiagnosis potentially leading to harmful treatment decisions. DOPA decarboxylase (DDC) shows promise as a cerebrospinal fluid (CSF) biomarker for DLB and Parkinson’s disease (PD), but quantitative assays are needed for its clinical implementation.

Introduction Click to copy section linkSection link copied! Ischemic heart disease remains the leading cause of death worldwide. (1) The beneficial effects of cardiac rehabilitation (CR) through physical exercise on the progression of the disease in postacute myocardial infarction patients are well-known. (2−4) CR has numerous beneficial cardiovascular, metabolic, psychological, and functional effects, overall improving both cardiovascular outcomes and overall patient well-being.

For the aim of this pilot, hypothesis-generating study, we retrospectively considered a consecutive series of 133 patients referring to the Center for Memory Disturbances, Section of Neurology of the University of Perugia. At baseline all patients underwent clinical neurological examination, neuropsychological assessment including Mini-Mental State Examination (MMSE) and Clinical Dementia Rating scale, cerebrospinal fluid (CSF) and blood collections.