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Articles by Feifei Chu
RNF2 mediates H2A ubiquitination to promote colitis via suppressing monocyte-macrophage transition in mice
Abstract Monocyte-macrophage transition is dysregulated in inflammatory bowel disease. While polycomb repressive complexes are crucial for maintaining cellular identity, their specific roles in colitis are poorly defined. Here, we show that Ring finger protein 2, a core catalytic subunit of polycomb repressive complex 1, regulates the monocyte-macrophage transition during colitis. It is highly expressed in the immature colon and circulating monocytes during ulcerative colitis.
Macrophage USP9X attenuates colitis by restricting oncostatin M production via K27-linked deubiquitination of STAT1
Abstract Dysregulated posttranslational modifications drive inflammatory bowel disease (IBD) pathogenesis, yet the specific roles of deubiquitinases in intestinal macrophages remain poorly characterized. Here, we identify ubiquitin-specific peptidase 9X (USP9X) as a critical negative regulator of intestinal inflammation. USP9X expression is reduced in UC patients and inversely correlated with disease severity.
Pre‐Expanded Fronto‐Scalp Flaps Combined With Botulinum Toxin and Laser Therapy for Secondary Large‐Scale Craniofacial Defects
1 Introduction As a vital anatomical structure and core identity marker, the face is essential to human function and social engagement [1]. Consequently, secondary facial defects have consistently been a primary focus and challenge in plastic and reconstructive surgery [2]. Etiologies leading to secondary facial defects include post-traumatic scars, pigmented nevi, verrucous nevi, and facial tumors [3-5]. Multiple factors underlie the high incidence of these defects.
Downregulation of circ‐RAPGEF5 inhibits colorectal cancer progression by reducing the expression of polypeptide N‐acetylgalactosaminyltransferase 3 (GALNT3)
CONFLICT OF INTEREST STATEMENT The authors declare no conflict of interest. Supporting Information Filename Description tox24278-sup-0001-FigureS1.tifTIFF image, 471.3 KB Figure S1: The expression of circ-RAPGEF5, miR-545-5p, and GALNT3 in CRC cells upon transfection. (A) The relative circ-RAPGEF5 level was detected in LoVo and HCT116 cells after transfecting with sh-NC or sh-circ-RAPGEF5 by qRT-PCR.
Itraconazole inhibits tumor growth via CEBPB‐mediated glycolysis in colorectal cancer
1 INTRODUCTION CRC is one of the most common tumor types in the digestive system with high morbidity and mortality in recent years.1 At present, radical surgery combined with chemoradiotherapy can benefit CRC patients in the short term, but most patients still relapse, with metastasis and chemotherapy resistance within several years after treatment, resulting in a poor prognosis for patients.2 Although large fruitful achievements have been made in pathogenesis and clinical transformation...
Long noncoding RNA THOR is highly expressed in colorectal cancer and predicts a poor prognosis
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