Feifei Chu

Abstract Dysregulated posttranslational modifications drive inflammatory bowel disease (IBD) pathogenesis, yet the specific roles of deubiquitinases in intestinal macrophages remain poorly characterized. Here, we identify ubiquitin-specific peptidase 9X (USP9X) as a critical negative regulator of intestinal inflammation. USP9X expression is reduced in UC patients and inversely correlated with disease severity.

1 Introduction As a vital anatomical structure and core identity marker, the face is essential to human function and social engagement [1]. Consequently, secondary facial defects have consistently been a primary focus and challenge in plastic and reconstructive surgery [2]. Etiologies leading to secondary facial defects include post-traumatic scars, pigmented nevi, verrucous nevi, and facial tumors [3-5]. Multiple factors underlie the high incidence of these defects.

CONFLICT OF INTEREST STATEMENT The authors declare no conflict of interest. Supporting Information Filename Description tox24278-sup-0001-FigureS1.tifTIFF image, 471.3 KB Figure S1: The expression of circ-RAPGEF5, miR-545-5p, and GALNT3 in CRC cells upon transfection. (A) The relative circ-RAPGEF5 level was detected in LoVo and HCT116 cells after transfecting with sh-NC or sh-circ-RAPGEF5 by qRT-PCR.