Feifei Lei

1 INTRODUCTION: PPAR ISOFORMS IN HEALTH AND DISEASES Peroxisome proliferator-activated receptors (PPARs) are transcription factors that belong to the nuclear receptor family, they can be activated by endogenous unsaturated and saturated fatty acids or synthetic ligands.1-4 PPAR-α, the first isoform of PPAR, was successfully cloned from the mouse liver in 1990 and is a new nuclear receptor that plays a key role in triglyceride and cholesterol homeostasis.2, 5 Two years later, all three PPAR...

ORIGINAL ARTICLE This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi:10.1111/sji.13305. Abstract Objective γδT cells are important innate immune cells that are involved in the occurrence and development of autoimmune diseases such as systemic lupus erythematosus (SLE).