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Felipe Takaesu on Muck Rack

Felipe Takaesu

As seen in: BioRxiv
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Articles

Lgr5+ intestinal stem cells are required for organoid survival after genotoxic injury

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By Joseph Lee, Antoine Gleizes, Felipe Takaesu, Taylor Hailstock
| BioRxiv
Abstract Progenitors and mature cells can maintain the intestinal epithelium by dedifferentiation and facultative intestinal stem cell (fISC) function when active ISCs (aISCs) are lost to damage. Here, we sought to model fISC activation in intestinal organoids with doxorubicin (DXR), a chemotherapeutic known to ablate Lgr5+ aISCs in vivo. We identified low and high doses of DXR compatible with long-term organoid survival.
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