Femke Munting

Abstract The organization of the genome in three-dimensional space is highly dynamic, yet how these dynamics are regulated and the role they play in genome function is poorly understood. Here we utilized acute depletion of NIPBL to characterize cohesin-mediated loop extrusion in vivo. We find that many chromatin loops are rapidly diminished upon loss of NIBPL, but some cohesin-dependent chromatin loops persist for multiple hours.

Femke Munting · Follow 11 min read · -- “Running” Models: Insights from the Big Data Bowl University of Texas McCombs MSBA Program: MIS382N Final Project Project by Téa McCormack, Femke Munting, Adithya Murali, Mallika Singh, Geer Zhang In the fast paced world of the NFL, predicting a player’s next move could be the difference between a game winning play or a devastating loss.

Abstract The organization of the genome in three-dimensional space is highly dynamic, yet how these dynamics are regulated and the role they play in genome function is poorly understood. Here, we utilized acute depletion of NIPBL to characterize the role of cohesin-mediated loop extrusion in vivo. Using this approach, we found that many chromatin loops are rapidly diminished upon loss of NIBPL, consistent with recent single locus imaging studies showing that chromatin loops are transient.