Fengcai shi on Muck Rack

Fengcai shi

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Hypoxia-induced BTN3A2 promotes glioma progression and chemoresistance via AKT/SP1/RAD51-mediated DNA damage

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By Zhixing Xu, SHANRUI PU, Jin Wu , Xiaobing Huang, Jintao Tian, Xingchang Li, Bohu Liu, Xinglong Yu, Jinxi Zhao, Xi Chen, Jun Pu, Shengjing Yuan, Fengcai shi
| Nature
Abstract Glioma remains a highly aggressive malignancy with frequent recurrence and resistance to radiotherapy and chemotherapy. BTN3A2 is a multifunctional regulatory protein originally implicated in γδ T-cell–mediated immune responses, yet its tumor-intrinsic role and mechanistic relevance in glioma are poorly defined. Here, BTN3A2 expression and prognostic associations were assessed in TCGA and CGGA cohorts and further validated by immunohistochemistry on tissue microarrays.
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