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Fengmin Yin on Muck Rack

Fengmin Yin

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Articles

Fuzuloparib enhances radiosensitivity of gain-of-function mutant p53 R273H NSCLC by promoting SLC7A11/GSH/GPX4 axis mediated ferroptosis

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By Mengjia Wu, Lei Zhang, Chenggang Xu, Mingjian Li, Chuanhui Cao, Wei Hu, Chaoyuan Pu, Wanxuan Weng, Fengmin Yin
| Nature Verified
Abstract Radiotherapy is a crucial therapeutic approach for the management of non-small cell lung cancer (NSCLC). Nevertheless, the radioresistance of NSCLC, particularly in cases involving the gain-of-function mutant p53, substantially limits its efficacy. According to recent research, mutant p53 R273H can recruit poly (ADP-ribose) polymerase (PARP)-1 on replicating DNA to promote tumor survival.
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