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Féodora Bertherat on Muck Rack

Féodora Bertherat

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Articles

Tau depletion in human neurons mitigates Aβ-driven toxicity - Molecular Psychiatry

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By Bryan Ng, Ajantha Abey, Darragh O’Brien, Sally A. Cowley, Féodora Bertherat
| Nature Verified
Abstract Alzheimer’s disease (AD) is an age-related neurodegenerative condition and the most common type of dementia, characterised by pathological accumulation of extracellular plaques and intracellular neurofibrillary tangles that mainly consist of amyloid-β (Aβ) and hyperphosphorylated tau aggregates, respectively. Previous studies in mouse models with a targeted knock-out of the microtubule-associated protein tau (Mapt) gene demonstrated that Aβ-driven toxicity is tau-dependent.
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