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Sex Hormone‐Dependent Modulation of Nrf2 and Its Association With Apoptosis, Metastasis, and Drug Resistance in Hepatocellular Carcinoma
1 Introduction Globally, hepatocellular carcinoma (HCC) is the sixth most common type of cancer and primarily occurs in individuals with chronic liver inflammation or cirrhosis [1]. Although variations in risk factors contribute to its uneven global distribution, HCC is generally more prevalent in men than in women across most populations [2]. The incidence of HCC is approximately three to four times higher in men than in women [1, 2].
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