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Domino Synthesis of Coumarins via Phosphine-Mediated Formal Oxa -[4 + 2] Cycloaddition: Discovering a Missing Recyclization of Maleimides with Salicylaldehydes Click to copy article link Article link copied!
General Procedure for Continuous-Flow Synthesis for Products 4b, 4d, 4e, 4f, 4r, and 4aa A solution containing maleimide (0.5 mmol, 1.0 equiv) and salicylaldehyde (0.5 mmol, 1.0 equiv) was prepared in ethanol (7 mL, 0.07 mol L–1) in a 10 mL Erlenmeyer flask. The mixture was briefly sonicated to ensure complete dissolution and then transferred to a 9 mL sample loop using a syringe.
Practical synthesis of (S)‐pyroglutamic acid
REFERENCES 1(a) , , , Tetrahedron: Asymmetry 2009, 20, 1581. (b) , J. Heterocyclic Chem. 2022, 59, 1660. 2, , , , J. Mol. Struct. 2019, 1178, 436. 3, , Helv. Chim. Acta 2004, 87, 2131. 4, , J. Org. Chem. 2002, 67, 1820. 5, Biochem. J. 1914, 8, 481. 6, Synthesis 1978, 1978, 290. 7, Tetrahedron Lett. 1980, 21, 2443. 8, , J. Am. Chem. Soc. 1952, 74, 2859. 9, J. Am. Chem. Soc. 1954, 76, 4613. 10, , , J. Serb. Chem. Soc. 1989, 54, 11. 11(a) , , , , , Tetrahedron Lett. 2013, 54, 3366. (b) , , , , Tetrahedron 2014, 70, 3284.
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