Fernando Paiva Conte on Muck Rack

Fernando Paiva Conte

As seen in: MDPI
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Articles

Vaccines | Free Full-Text | Sph2(176-191) and Sph2(446-459): Identification of B-Cell Linear Epitopes in Sphingomyelinase 2 (Sph2), Naturally Recognized by Patients Infected by Pathogenic Leptospires

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By Angela Barbosa, Laura Sant’Anna Ataides, Fernando Paiva Conte, Lourdes Isaac
| MDPI
Abstract : Sphingomyelin is a major constituent of eukaryotic cell membranes, and if degraded by bacteria sphingomyelinases may contribute to the pathogenesis of infection. Among Leptospira spp., there are five sphingomyelinases exclusively expressed by pathogenic leptospires, in which Sph2 is expressed during natural infections, cytotoxic, and implicated in the leptospirosis hemorrhagic complications.
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