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Finian J. Leeper on Muck Rack

Finian J. Leeper

As seen in: Royal Society of Chemistry, BioRxiv
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Articles

Identification and characterization of thiamine analogues with antiplasmodial activity

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By Terence Ho, Alex Chan, Finian J. Leeper, Kai Matuschewski
| BioRxiv
Abstract Thiamine is metabolized into thiamine pyrophosphate (TPP), an essential enzyme cofactor. Previous work has shown that oxythiamine, a thiamine analogue, is metabolized by thiamine pyrophosphokinase (TPK) into oxythiamine pyrophosphate (OxPP) within the malaria parasite Plasmodium falciparum, and then inhibits TPP-dependent enzymes, killing the parasite in vitro and in vivo.
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Open-chain thiamine analogues as potent inhibitors of thiamine pyrophosphate (TPP)-dependent enzymes

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By Alex Chan, Terence Ho, Finian J. Leeper
| Royal Society of Chemistry Verified
Open-chain thiamine analogues as potent inhibitors of thiamine pyrophosphate (TPP)-dependent enzymes Alex H.Y. Chan, Terence Ho and Finian J. Leeper Abstract A common approach to studying thiamine pyrophosphate (TPP)-dependent enzymes is by chemical inhibition with thiamine/TPP analogues which feature a neutral aromatic ring in place of the positive thiazolium ring of TPP. These are potent inhibitors but their preparation generally involves multiple synthetic steps to construct the central ring.
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