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Fiona Mary Gribble on Muck Rack

Fiona Mary Gribble

As seen in: Nature
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Distinct brain regions mediate regulation of food intake in response to GIPR agonism or antagonism

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By Jo Lewis, Mireia Montaner, Danaé Nuzzaci, Norio Harada, Nobuya Inagaki, W. Scott Dodson, Patrick J. Knerr, Jonathan D. Douros, Frank Reimann, Paula-Peace James-Okoro, Fiona Mary Gribble
| Nature Verified
Abstract The development of dual agonists for the glucagon-like peptide-1 receptor (GLP-1R) and glucose-dependent insulinotropic polypeptide receptor (GIPR) has been a landmark moment in the treatment of type 2 diabetes and obesity. However, for reasons that are incompletely understood, in preclinical and clinical studies, adding either a GIPR agonist or GIPR antagonist to GLP-1R agonism causes additional weight loss1.
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